Medical Condition That Causes Penis to Start Growing Again
On this folio:
- What is Peyronie's disease?
- How common is Peyronie's disease?
- Who is more than likely to have Peyronie's disease?
- What are the complications of Peyronie's illness?
- What are the signs and symptoms of Peyronie's disease?
- What causes Peyronie's disease?
- How do health care professionals diagnose Peyronie's illness?
- How do health care professionals treat Peyronie's disease?
- Can I prevent Peyronie'southward affliction?
- Clinical Trials for Peyronie's disease
What is Peyronie's disease?
Peyronie'south affliction is a disorder in which scar tissue, chosen plaque, forms under the skin of the penis—the male organ used for urination and sex activity.
The plaque builds upward inside the penis, in the thick rubberband membrane called the tunica albuginea. The tunica albuginea helps keep the penis strong during an erection. The plaque can develop anywhere along the penis.
As it develops, the plaque pulls on the surrounding tissues and causes the penis to curve or bend, usually during an erection. Curves in the penis can make erections painful and may make sexual intercourse painful, hard, or impossible.
The plaque that develops in Peyronie'due south disease
- is caused by injury to your penis or by an autoimmune disease
- is not the same plaque that can develop in a person'south arteries
- is beneficial—not malignant and not a tumor
Peyronie'due south disease occurs in 2 phases.
Acute stage
During the acute phase, the plaque forms, and this phase tin terminal up to 18 months.ane During this phase
- Inflammation may occur and plaque forms on your penis.
- Your penis starts to curve.
- Your penis may injure without an erection.
- Erections may become painful when scars develop.
Chronic phase
The chronic phase occurs after the plaque has formed. Usually, the chronic phase begins 12 to 18 months subsequently your symptoms first announced.ane During this phase
- Plaque and penile curvature may stabilize and not get worse.
- The hurting in your penis may lessen.
- Erectile dysfunction (ED) may develop or become worse.
How mutual is Peyronie's disease?
Approximately 1 in 100 men in the United States over the age of xviii accept been diagnosed with Peyronie's illness. However, based on studies of men who reported having symptoms of Peyronie's disease, researchers estimate that the actual number of men who have Peyronie's illness is more than 1 in 10.2,3
The hazard of developing Peyronie's disease increases with age.one It is less common for men in their 20s and 30s to have Peyronie'southward disease.i
Who is more likely to accept Peyronie's disease?
You may be at college risk of developing Peyronie's affliction if you
- engage in vigorous sexual or nonsexual activities that cause micro-injuries to the penis
- have certain connective tissue and autoimmune disorders
- have a family history of Peyronie's affliction
- are older
- have diabetes and erectile dysfunction
- have a history of prostate cancer treatment with surgery
Vigorous sexual and nonsexual activities
Men whose sexual or nonsexual activities (such equally sports) cause micro-injuries to the penis are more than likely to develop Peyronie'due south disease.
Connective tissue and autoimmune disorders
If y'all take certain connective tissue or autoimmune disorders, you may accept a higher chance of developing Peyronie's disease.
Connective tissue is specialized tissue that supports, joins, or separates different types of tissues and organs in your trunk. Connective tissue disorders may affect your joints, muscles, and skin. Some disorders associated with Peyronie'south disease include
- Dupuytren's disease, too known as Dupuytren's contracture. In this condition, the connective tissue in the palms of the easily shortens and thickens. This results in the permanent angle of the outer fingers. It is not clear why men with Peyronie's disease are more likely to develop Dupuytren'due south disease.
- plantar fasciitis, which is inflammation of the thick tissue on the bottom of the foot that creates the arch of the foot.
- scleroderma, which is the abnormal growth of thick, hard patches of connective tissue. Scleroderma tin also cause swelling or pain in muscles and joints.
In autoimmune disorders, the trunk's immune arrangement attacks the body's own cells and organs. Autoimmune disorders associated with Peyronie'due south disease include
- systemic lupus erythematosus, which causes inflammation and damage to various body tissues including the joints, pare, kidneys, heart, lungs, blood vessels, and brain
- Sjögren'south syndrome, which causes inflammation and damage to the glands that make tears and saliva
- Behçet's disease, which causes inflammation of the claret vessels
Family history of Peyronie's affliction
Medical experts believe that Peyronie's disease may run in some families. For instance, if your male parent or blood brother has Peyronie's disease, you may take an increased chance of getting the disease too.
Aging
Your chance of getting Peyronie's illness increases with age. Historic period-related changes in the tissues in the penis may cause it to be more hands injured and less likely to heal well.
Diabetes with erectile dysfunction
Men with diabetes-associated ED have a 4 to v times college gamble of developing Peyronie's disease compared with the general population.4
Prostate cancer treatment with surgery
Your chance of getting Peyronie's disease increases afterward surgery for prostate cancer. Medical experts believe this is related to ED developed afterwards surgery for prostate cancer.5
What are the complications of Peyronie'due south disease?
Complications of Peyronie'south disease may include
- the inability to accept sexual intercourse due to penile curvature
- ED
- emotional distress, depression, or anxiety well-nigh sexual abilities or the advent of the penis
- stress in a relationship with a sexual partner
- problems fathering a child because intercourse is difficult
What are the signs and symptoms of Peyronie'south illness?
The signs and symptoms of Peyronie's disease may include
- difficult lumps on one or more sides of the penis
- hurting during sexual intercourse or during an erection
- a curve in the penis with or without an erection
- changes in the shape of the penis, such as narrowing or shortening
- ED
These may develop slowly or appear apace and tin can be mild to astringent. In many cases, the pain decreases over time, although the bend in the penis may remain.i Problems with intercourse or ED tin occur during either stage.
What causes Peyronie's disease?
Medical experts practise not know the exact cause of Peyronie's disease but believe that it may exist the result of
- acute or chronic injury to the penis
- autoimmune disease
Peyronie'due south disease is non contagious or caused past any known transmittable illness.
Injury to the penis
Medical experts believe that hitting or bending the penis may hurt the tissues inside. These injuries can happen during sex, athletic activity, or an blow. It tin happen once, an acute injury, or repeatedly over time, a chronic injury.
The injury may cause haemorrhage and swelling inside the elastic membrane in the penis, or the tunica albuginea. When the injury heals, scar tissue may form, and a plaque tin develop. The hard plaque pulls at the surrounding tissues and causes the penis to curve.
You may not be aware of micro-injuries to your penis when they occur. Researchers accept constitute that many patients are unable to think a specific incident just before symptoms started.1
Autoimmune affliction
Men who have an autoimmune disease may develop Peyronie'south affliction if the immune arrangement attacks cells in the penis. This can lead to inflammation in the penis. Scar tissue may class and develop into plaque. Run across connective tissue and autoimmune disorders for more than on autoimmune disorders associated with Peyronie's illness.
How practice health care professionals diagnose Peyronie's disease?
Men with Peyronie'due south illness are usually referred to a urologist—a doctor who specializes in sexual and urinary problems.
A urologist diagnoses Peyronie'south affliction based on your medical and family unit history and a physical exam.
Imaging tests are unremarkably not necessary to diagnose Peyronie's illness simply may be used to assemble additional data well-nigh the plaque.
Medical and family unit history
The urologist will ask about your medical and family history. Some questions might be
- When did your symptoms begin?
- Do you feel pain during an erection or at other times?
- Practice yous have erection problems or problems with sexual intercourse?
- Does anyone in your family have Peyronie's disease or other medical conditions?
- Are you taking any medicines? If and so, what are they?
- Do you have other medical problems or atmospheric condition?
Concrete exam
A urologist can usually experience plaques in the penis whether information technology is erect or not.
If the urologist needs to examine your penis during an erection, you will receive an injectable medicine that will cause an erection. Your urologist may also ask you to take pictures of your erect penis at home to evaluate the curvature during your follow-up visits.
How practise health care professionals treat Peyronie's disease?
The goal of treatment is to reduce hurting, attain a straight or close-to-straight penis, and restore and maintain the ability to accept intercourse.
Not all men with Peyronie'due south affliction need treatment. In a very few cases, Peyronie's illness goes abroad without treatment.1
Also, you may not need treatment if you have6
- small plaques
- little or no bend to your penis
- no pain
- no bug with sexual intercourse
- no urinary problems
If you need treatment, your urologist may recommend nonsurgical treatments or surgery depending on the severity of your symptoms, how much your penis curves, and whether your Peyronie's affliction is in the acute or chronic phase.
Your urologist volition discuss your treatment options with yous and review possible side effects and outcomes.
Besides treatment, your urologist may recommend lifestyle changes to reduce the risk of ED associated with Peyronie'south disease.
Nonsurgical treatments
Nonsurgical treatments include injections, oral medicines, and medical therapies. They may exist used when Peyronie'due south disease is in the acute phase.
Injections. Injecting a medicine directly into plaques, called intralesional injections, can be washed in the acute phase. The injection site is often numbed before the shot. These treatments can be done in the physician'southward function.
- Collagenase. Intralesional collagenase injections (Xiaflex) are currently the only FDA-approved treatment for Peyronie's illness. Collagenase is an enzyme that helps break down the substances that make up plaques. Breaking down the plaques reduces penile curving and improves erectile function. This treatment is canonical for men with penises curving more than 30 degrees.7
- Verapamil. Verapamil is used to treat loftier claret pressure and may reduce penis pain and curving when injected into the plaque.1
- Interferon-alpha 2b. Interferon is a protein fabricated by white blood cells. Studies show that it reduces pain, penile curving, and plaque size.vii
Oral medicines. There are no oral medicines that finer treat penile curvature at this time.7 Yet, potassium para-aminobenzoate is used to care for Dupuytren'due south contracture and may reduce plaque size. Information technology has no effect on penile curving.
If you experience pain, your urologist may propose you accept nonsteroidal anti-inflammatory drugs (NSAIDS).
Nondrug medical therapies. Other medical therapies to treat Peyronie'south disease are still being studied to encounter if they work.seven These therapies include
- mechanical traction and vacuum devices—aimed at stretching or angle the penis to reduce curving
- shockwave therapy—focused, low-intensity electroshock waves directed at the plaque may be used to reduce paini
Surgery
A urologist may recommend surgery to remove plaque or aid straighten the penis during an erection. Surgery may be recommended for men who have Peyronie's disease when
- symptoms accept not improved
- erections or intercourse, or both, are painful
- the curve in the penis prevents sexual intercourse
Medical experts recommend you don't have surgery until your plaque and penis curving stabilize.one
Several types of surgeries treat Peyronie'south affliction. Your urologist volition examine the plaque on your penis and consider the best type of surgery for y'all. An ultrasound will show the exact location and size of the plaque.
Some men may develop complications subsequently surgery, and sometimes surgery does not correct some effects of Peyronie's disease such equally the shortening of the penis.
Grafting. In this surgery, your urologist will remove the plaque and replace information technology with a patch of tissue that was taken from some other function of your body, such as peel or a vein from your leg; grown in a laboratory; or from organ donors.
This procedure may straighten the penis and restore some length that was lost due to Peyronie's disease.
Some men may experience numbness of the penis and ED after the procedure.
Plication. In plication surgery, your urologist will remove or compression a slice of the tunica albuginea from the side of the penis reverse the plaque to help straighten the penis.
This process is less likely to crusade numbness or ED.
Plication cannot restore the length or girth of the penis, and the penis may become shorter.
Device implantation. Penile implants may be considered if a man has both Peyronie's disease and ED.
A urologist implants a device into the penis that tin can crusade an erection. The device may help straighten the penis during an erection.
In some cases, the implant alone will straighten the penis adequately. If the implant lonely does not straighten the penis, a urologist may combine implantation with ane of the other two surgeries.
Can I forestall Peyronie'due south affliction?
Researchers do not know how to prevent Peyronie'southward disease. At this time, diet and nutrition have non been found to play a role in preventing Peyronie's disease.ane
Clinical Trials for Peyronie'south affliction
The NIDDK conducts and supports clinical trials in many diseases and conditions, including urologic diseases. The trials look to find new ways to prevent, observe, or treat disease and improve quality of life.
What are clinical trials for Peyronie'due south disease?
Clinical trials—and other types of clinical studies—are part of medical enquiry and involve people like you. When you volunteer to have role in a clinical study, y'all assist doctors and researchers learn more than about disease and better health care for people in the future.
Researchers are studying many aspects of treating Peyronie's disease including the efficacy of
- unlike medicines
- other types of nonsurgical treatment
Find out if clinical studies are right for you.
What clinical studies for Peyronie'due south illness are looking for participants?
You lot can view a filtered list of clinical studies on Peyronie's disease that are open and recruiting at www.ClinicalTrials.gov. You can aggrandize or narrow the listing to include clinical studies from industry, universities, and individuals; however, the NIH does non review these studies and cannot ensure they are safe. Always talk with your wellness care professional before y'all participate in a clinical written report.
What take we learned nearly Peyronie's disease from NIDDK-funded research?
The NIDDK has supported inquiry projects to learn more than almost how plaque develops and the role of genes.
References
Source: https://www.niddk.nih.gov/health-information/urologic-diseases/penile-curvature-peyronies-disease
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